"With this issue the New England Journal of Medicine marks its 200th anniversary." While the January, 1812, issue was delivered by horseback, today's January 5, 2012, issue (v.366, no.1) is distributed not only in print but also through the web to a wide audience. Its pages provide a record of the changes in medical science and society during that period. The anniversary issue includes "A Reader's Guide to 200 Years of the New England Journal of Medicine" and an interactive timeline.
In addition, see their anniversary site for more delving into medical history as revealed by study of NEJM published articles. You can vote monthly to select the most important articles, take the historical image challenges, and even share your own story.